Scancell’s second ImmunoBody, SCIB2, will use a new lipid nanoparticle formulation and will be delivered via a standard injection to patients in the planned Phase I/II study, rather than using electroporation.
A known lipid carrier is used in the formulation, with the nanoparticles optimised to deliver SCIB2 (a DNA vaccine) efficiently to immune cells without degradation of the DNA.
Based on preclinical studies, Scancell believes the delivery of the ImmunoBody to the immune cells using the nanoparticle formulation should be at least comparable to, and could be better than, using electroporation.
SCIB2 is being developed in a collaboration between Scancell and Cancer Research UK (CRUK), and is designed to induce an immune response against the tumour-associated antigen, NY-ESO-1, which is expressed in many different tumours (including sarcomas, neuroblastomas, myeloma, NSCLC, prostate and breast cancers).
CRUK is responsible for funding and conducting the Phase I/II clinical trial with SCIB2 in NSCLC. At the end of the study, Scancell will have the option (no terms disclosed) to acquire the data to support the further development of SCIB2. No timings have been disclosed for the Phase I/II study.