GSK PLC - Latozinemab data read out

Issued: 21 October 2025, London UK

GSK provides update on latozinemab

LONDON, 21 October 2025 -GSK plc (LSE/NYSE: GSK) and Alector, Inc. (Nasdaq: ALEC) today confirmed headline results from the INFRONT-3 clinical trial evaluating latozinemab in individuals with frontotemporal dementia due to a mutation in the progranulin gene (FTD-GRN).

Although latozinemab treatment resulted in a statistically significant effect on the INFRONT-3 biomarker co-primary endpoint of plasma progranulin (PGRN) concentrations[i], latozinemab did not show benefit on the clinical co-primary endpoint of slowing FTD-GRN progression. The secondary and exploratory endpoints also did not demonstrate treatment-related effects on FTD-GRN. Preliminary safety data have not highlighted any major safety concerns at present. More in-depth analysis of the data is ongoing.

Based on these results, the open-label extension portion of the INFRONT-3 trial and the continuation study for latozinemab will be discontinued.

Given the unmet medical need in neurodegeneration, innovation in this area is still needed. GSK will evaluate the totality of these data to inform future research.

The full results of the INFRONT-3 study will be presented at an upcoming medical congress.  

GSK and Alector Collaboration

In July 2021, GSK and Alector entered into a collaboration and license agreement to collaborate on the global development and commercialization of progranulin-elevating monoclonal antibodies, including latozinemab. Alector led the global clinical development of latozinemab through Phase 2 proof-of-concept. Thereafter, Alector and GSK shared development responsibilities and all costs for global development were divided between the two companies.

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About GSK

GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com.

Cautionary statement regarding forward-looking statements

GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described in the "Risk Factors" section in GSK's Annual Report on Form 20-F for 2024, and GSK's Q2 Results for 2025.

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References

i GSK data on file