Bristol Myers Squibb just announced that RELATIVITY-047 evaluang combinaon of its an-LAG-3 Relatlimab with Opdivo had a significant benefit on progression-free survival. The Phase 2 3 trial in paents with untreated or unresectable melanoma showed a PFS of 10.12 months with the relatlimab combo compared to 4.63 months with Opdivo alone. This is the first me a treatment regimen has shown benefit over PD-1 alone in melanoma. These data to be presented at ASCO (American Society for Clinical Oncology) meeng (June 2021) are clearly posive for Immutep's partnered an-LAG-3 LAG525 currently in Phase II with Novars. With Immutep's Eilagimod alpha ("ei") also showing posive benefits in combinaon with PD-1 in HNSCC (head and neck cancer) and non-small cell lung cancer ("NSCLC"), these new data highlight the potenal of Immutep's in-house and partnered programme. Addional new data from the TACTI-002 Phase 2 in HNSCC and NSCLC and TACTI-004 in solid tumours will be released during ASCO on 4th June. With final AIPAC survival data also expected over the course of 2021E, we reiterate our OUTPERFORM recommendaon and AUD$ 0.900 target price.
20 May 2021
BMS shows LAG-3 - PD-1 combo boosts PFS in melanoma
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BMS shows LAG-3 - PD-1 combo boosts PFS in melanoma
Bristol Myers Squibb just announced that RELATIVITY-047 evaluang combinaon of its an-LAG-3 Relatlimab with Opdivo had a significant benefit on progression-free survival. The Phase 2 3 trial in paents with untreated or unresectable melanoma showed a PFS of 10.12 months with the relatlimab combo compared to 4.63 months with Opdivo alone. This is the first me a treatment regimen has shown benefit over PD-1 alone in melanoma. These data to be presented at ASCO (American Society for Clinical Oncology) meeng (June 2021) are clearly posive for Immutep's partnered an-LAG-3 LAG525 currently in Phase II with Novars. With Immutep's Eilagimod alpha ("ei") also showing posive benefits in combinaon with PD-1 in HNSCC (head and neck cancer) and non-small cell lung cancer ("NSCLC"), these new data highlight the potenal of Immutep's in-house and partnered programme. Addional new data from the TACTI-002 Phase 2 in HNSCC and NSCLC and TACTI-004 in solid tumours will be released during ASCO on 4th June. With final AIPAC survival data also expected over the course of 2021E, we reiterate our OUTPERFORM recommendaon and AUD$ 0.900 target price.