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13 Mar 2025

ACF Thematic Research Regenerative Medicine Diabetes Treatment & Innovation 13032025

CRISPR Therapeutics AG (CRSP:NYSE), 0 | CRISPR Therapeutics AG (CRSP:NAS), 0 | DEXCOM (DXCM:NYSE), 0 | DexCom, Inc. (DXCM:NAS), 0 | Eli Lilly and Co (LLY:NYSE), 0 | Eli Lilly and Company (LLY:NYS), 0 | Hims & Hers Health, Inc. Class A (HIMS:NYS), 0 | INSULET (PODD:NYSE), 0 | Insulet Corporation (PODD:NAS), 0 | Kadimastem Ltd. (KDST:TAE), 0 | Medtronic plc. Ordinary Shares (MDT:NYSE), 0 | Medtronic Plc (MDT:NYS), 0 | NLS Pharmaceutics Ltd. (NLSP:NAS), 0 | Oramed Pharmaceuticals Incorporated (ORMP:TAE), 0 | Sana Biotechnology, Inc. (SANA:NAS), 0 | Sanofi (SAN:EPA), 0 | Sanofi SA (SAN:PAR), 0 | Senseonics Holdings Inc (SENS:NYSE), 0 | Senseonics Holdings, Inc. (SENS:ASE), 0 | Tandem Diabetes Care Inc (TNDM:NYSE), 0 | Tandem Diabetes Care, Inc. (TNDM:NAS), 0 | Teladoc (TDOC:NYSE), 0 | Teladoc Health, Inc. (TDOC:NYS), 0 | Tiziana Life Sciences Ltd. (TLSA:NAS), 0 | VERTEX PHARMACEUTICALS (VRTX:NYSE), 0 | Vertex Pharmaceuticals Incorporated (VRTX:NAS), 0

- Research Team ACF
- 33 pages

Diabetes mellitus, Type 1 (T1D) and Type 2 (T2D, 85-90% of cases), is a USD ~75bn global therapy market. Global economic costs of diabetes may exceed USD1 trn today and USD 450bn in the US, suggesting a pressing global health challenge. Diabetes is a chronic metabolic disorder characterized by high blood sugar levels. In 2024, consensus global estimates suggested there were ~800m adult diabetes sufferers. In 2021, according to the IDF there >530m sufferers globally. For 2027E we modestly forecas ....

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ACF Thematic Research Regenerative Medicine Diabetes Treatment & Innovation 13032025

CRISPR Therapeutics AG (CRSP:NYSE), 0 | CRISPR Therapeutics AG (CRSP:NAS), 0 | DEXCOM (DXCM:NYSE), 0 | DexCom, Inc. (DXCM:NAS), 0 | Eli Lilly and Co (LLY:NYSE), 0 | Eli Lilly and Company (LLY:NYS), 0 | Hims & Hers Health, Inc. Class A (HIMS:NYS), 0 | INSULET (PODD:NYSE), 0 | Insulet Corporation (PODD:NAS), 0 | Kadimastem Ltd. (KDST:TAE), 0 | Medtronic plc. Ordinary Shares (MDT:NYSE), 0 | Medtronic Plc (MDT:NYS), 0 | NLS Pharmaceutics Ltd. (NLSP:NAS), 0 | Oramed Pharmaceuticals Incorporated (ORMP:TAE), 0 | Sana Biotechnology, Inc. (SANA:NAS), 0 | Sanofi (SAN:EPA), 0 | Sanofi SA (SAN:PAR), 0 | Senseonics Holdings Inc (SENS:NYSE), 0 | Senseonics Holdings, Inc. (SENS:ASE), 0 | Tandem Diabetes Care Inc (TNDM:NYSE), 0 | Tandem Diabetes Care, Inc. (TNDM:NAS), 0 | Teladoc (TDOC:NYSE), 0 | Teladoc Health, Inc. (TDOC:NYS), 0 | Tiziana Life Sciences Ltd. (TLSA:NAS), 0 | VERTEX PHARMACEUTICALS (VRTX:NYSE), 0 | Vertex Pharmaceuticals Incorporated (VRTX:NAS), 0

Published: 13 Mar 2025
Author: Research Team ACF
Pages: 33

Diabetes mellitus, Type 1 (T1D) and Type 2 (T2D, 85-90% of cases), is a USD ~75bn global therapy market. Global economic costs of diabetes may exceed USD1 trn today and USD 450bn in the US, suggesting a pressing global health challenge. Diabetes is a chronic metabolic disorder characterized by high blood sugar levels. In 2024, consensus global estimates suggested there were ~800m adult diabetes sufferers. In 2021, according to the IDF there >530m sufferers globally. For 2027E we modestly forecas ....

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KDST + NLSP Combined Core Investment Case 29052025

Companies: LLY SENS CRSP VRTX PODD SAN LLY DXCM TNDM DXCM TDOC MDT TDOC VRTX CRSP KDST MDT SENS NLSP ORMP SAN PODD TLSA HIMS SANA TNDM

Nothing new – strong Genzyme but weak diabetes and fledgling Praluent

Companies: Sanofi SA

ORMP: Upcoming Expected Milestones Include OraTech Spin-Off & IPO, Launch of Phase 3 Trial

Companies: ORAMED PHARMACEUTICALS (ORMP:NYSE)Oramed Pharmaceuticals Incorporated (ORMP:NAS)

Amgen-Praluent injunction risky

Companies: Sanofi SA

Attractive Eli Lilly (LLY) Credit Profile

Companies: Eli Lilly and Company

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